Tip-enhanced ablation and ionization mass spectrometry for nanoscale chemical analysis

Tip-enhanced ablation and ionization mass spectrometry for nanoscale chemical analysis

Spectroscopic methods with nanoscale lateral resolution are becoming essential in the fields of physics, chemistry, geology, biology, and materials science. However, the lateral resolution of laser-based mass spectrometry imaging (MSI) techniques has so far been limited to the microscale. This report presents the development of tip-enhanced ablation and ionization time-of-flight mass spectromet...

Selective Reagents for Chemical Ionization Mass Spectrometry

Much of the power of chemical ionization mass spectrometry stems from the finding that the characteristics of the Cl mass spectrum produced is dependent on both the nature of the reagent gas and the type of ion-molecule reaction used to ionize the sample. Different structural information can be obtained with different reagent gases. As a consequence, it is possible to control the type and quant...

Solvent gradient electrospray for laser ablation electrospray ionization mass spectrometry.

Most electrospray based ambient ionization techniques, e.g., laser ablation electrospray ionization (LAESI), utilize a fixed spray solution composition. Complex samples often contain compounds of different polarity that exhibit a wide range of solubilities in the electrospray solvent. Thus, the fixed spray solution composition limits the molecular coverage of these approaches. Two-barrel theta ...

Characterization of extreme ultraviolet laser ablation mass spectrometry for actinide trace analysis and nanoscale isotopic imaging

Remote laser ablation electrospray ionization mass spectrometry for non-proximate analysis of biological tissues.

RATIONALE We introduce remote laser ablation electrospray ionization (LAESI), a novel, non-proximate ambient sampling technique. Remote LAESI allows additional analytical instrumentation to be incorporated during sample analysis. This work demonstrates the utility of remote LAESI and, when combined with optical microscopy, allows for the microscopy-guided sampling of biological tissues. METHO...